| Visitor Team vs Home Team | W-L | Score | Date |
|---|---|---|---|
| Fort Pierce Westwood vs. Centennial | L | 33 - 9 | 09/10/2010 07:00 PM |
| Sebastian River vs. Centennial | L | 35 - 7 | 09/17/2010 07:00 PM |
| Fort Pierce Central vs. Centennial | L | 14 - 7 | 09/24/2010 07:00 PM |
| South Fork vs. Centennial | W | 3 - 27 | 10/01/2010 07:00 PM |
| Centennial vs. Treasure Coast | L | 13 - 21 | 10/08/2010 07:00 PM |
| Vero Beach vs. Centennial | L | 17 - 0 | 10/22/2010 08:05 PM |
| Jupiter vs. Centennial | W | 0 - 21 | 10/29/2010 07:00 PM |
| Centennial vs. Palm Beach Gardens | L | 7 - 14 | 11/05/2010 07:00 PM |
| Port St. Lucie vs. Centennial | W | 21 - 49 | 11/12/2010 07:00 PM |
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